Optimizing inventory in the supply chain is a very important goal in the logistic business process, considering that optimized inventory directly affects the efficiency and profitability of the process. The aim of manufacturing, distribution and trading companies and also companies that provide complete logistical support is maximization of reducing inventory, while maintaining a certain level of services they provide for their own customers to become and remain competitive in the market. For this reason, different models and methods used in inventory optimization today are increasingly developing in order to achieve better and more efficient results. Considering the increasing demands of the market, companies are forced to turn to new and better ways of doing business. For this purpose this paper presents various models and methods, which provide highly efficient inventory management and may incerase the optimization opportunities within the supply chain.